abstract：:Sixteen chronic myeloid leukaemia (CML) patients in remission were tested with solubilized membrane antigens from CML leukaemic cells, CML blasts, AML blasts and ALL blasts for cellular immunity in vitro by lymphocyte transformation (LT) and leucocyte migration inhibition (LMI) assays. Twelve CML patients in remission...

journal_title：British journal of cancer

authors： Gangal SG,Damle NK,Khare AG,Advani SH

更新日期：1979-09-01 00:00:00

abstract：:Local infiltrates of eosinophilic leucocytes and macrophages and the deposition of acid mucopolysaccharides (AMPS) in 72 operable primary lung cancers and 17 isolated pulmonary metastases of known origin were correlated to tumour stage (radically or non-radically operable) and clinical course, by following the patient...

journal_title：British journal of cancer

authors： Kolb E,Müller E

更新日期：1979-09-01 00:00:00

abstract：:A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus ...

journal_title：British journal of cancer

authors： Higgins PJ,Tong C,Borenfreund E,Okin RS,Bendich A

更新日期：1979-08-01 00:00:00

abstract：:The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholesterol : phosphatidic...

journal_title：British journal of cancer

authors： Richardson VJ,Ryman BE,Jewkes RF,Jeyasingh K,Tattersall MN,Newlands ES,Kaye SB

更新日期：1979-07-01 00:00:00

abstract：:In a study of 157 patients with lymphoid malignancy, the phenotype of the tumour cells was correlated with the histological classification of the tumour using the Rappaport and the Kiel classifications. The markers used included E, Fc gamma, Fc micron (IgM) and C3d rosetting, estimation of SIg and CyIg, and tests for ...

journal_title：British journal of cancer

authors： Habeshaw JA,Catley PF,Stansfeld AG,Brearley RL

更新日期：1979-07-01 00:00:00

abstract：:gamma-Irradiated rat hepatoma cells are immunogenic in syngeneic WAB/Not rats, so that immunized animals are protected against tumour-cell challenge and circulating tumour-specific antibody is produced. Treatment of the immunizing cells with glutaraldehyde at concentrations of 0.001% or greater for 30 min rendered the...

journal_title：British journal of cancer

authors： Price MR,Dennick RG,Robins RA,Baldwin RW

更新日期：1979-06-01 00:00:00

abstract：:In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenol...

journal_title：British journal of cancer

authors： Hardell L,Sandström A

更新日期：1979-06-01 00:00:00

abstract：:Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross ela...

journal_title：British journal of cancer

authors： Masters JR,Millis RR,King RJ,Rubens RD

更新日期：1979-05-01 00:00:00

abstract：:Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...

journal_title：British journal of cancer

authors： Selby PJ,Heyderman E,Gibbs J,Peckham MJ

更新日期：1979-05-01 00:00:00

abstract：:When L2C leukaemic B lymphocytes from guinea-pigs were incubated in vitro with antibody directed to their surface immunoglobulin (Ig), a rapid rise in intracellular adenosine 3':5'-phosphate (cyclic adenosine monophosphate, cAMP) was observed. Estimation of cAMP was by a protein-binding assay using bovine adrenal prot...

journal_title：British journal of cancer

authors： Virji M,Stevenson GT

更新日期：1979-04-01 00:00:00

abstract：:Bilateral kidney ligation of mice immediately before injection of misonidazole (MIS) prolongs the plasma half-life of this radiosensitizer from about 2 h (in normal mice) to 10-11 h, similar to that in man. Kidney ligation does not, however, change the relative proportions of MIS and its O-demethylated metabolite, Ro-...

journal_title：British journal of cancer

authors： Brown JM,Yu NY,Workman P

更新日期：1979-03-01 00:00:00

abstract：:Transformation of primary hamster embryo cells was investigated using 3-methylcholanthrene (MCA), a combination of MCA and 12-O-tetradecanoylphorbol-13-acetate (TPA), and initiation with MCA or dibenz(a,h)anthracene (DBA) followed by promotion with TPA. Evidence for transformation was (a) abnormal cellular morphology,...

journal_title：British journal of cancer

authors： Poiley JA,Raineri R,Pienta RJ

更新日期：1979-01-01 00:00:00

abstract：:The influence of anaesthetics on the in vivo response of B16 melanoma to melphalan was studied using an in vitro cell-survival assay. Three anaesthetics were used, Saffan (Althesin) Sagatal (Nembutal) and Hypnorm. When Saffan was administered to tumour-bearing animals before melphalan there was a significant increase ...

journal_title：British journal of cancer

authors： Peacock JH,Stephens TC

更新日期：1978-12-01 00:00:00

abstract：:The formation of cyclic AMP was studied in normal liver, subcutaneous hepatomas derived from MH1C1 cells, and premalignant liver and primary hepatomas induced by the carcinogens 2-acetylaminofluorene (AAF) and 4-dimethylamino-azobenzene (DAB). While only very slight effects of prostaglandins (PG) were seen in slices o...

journal_title：British journal of cancer

authors： Brønstad GO,Christoffersen T,Johansen EJ,Oye I

更新日期：1978-12-01 00:00:00

abstract：:Two transplantable, highly immunogenic syngeneic C57BL fibrosarcomas, FS1 and FS6, were shown to have tumour-specific rejection antigens, as shown by excision of the primary tumours and i.p. or i.m. injection of graded doses of the specific and unrelated tumour cells. I.p. challenge with tumour cells induced a large a...

journal_title：British journal of cancer

authors： Evans R,Booth CG,Spencer F

更新日期：1978-11-01 00:00:00

abstract：:Combination chemotherapy with cytosine arabinoside, cyclophosphamide and L-asparaginase (Asnase) was given to 22 children with acute lymphocytic leukaemia (ALL) with a white-cell count greater than 30 X 10(9)/1, and other features suggestive of poor prognosis. Complete remission was induced in all patients--in 19 afte...

journal_title：British journal of cancer

authors： Ekert H,Waters KD,Smith PJ,Matthews RN,Ellis WM

更新日期：1978-11-01 00:00:00

abstract：:C57BL mice were given local irradiation to 2 cm2 of the lower abdomen in the dose range 16--24 Gy. There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine. When the radiosensitizer misonidazole was given in a single dose shortly before irradia...

journal_title：British journal of cancer

authors： Rostom AY,Kauffman SL,Steel GG

更新日期：1978-10-01 00:00:00

abstract：:A crude membrane fraction isolated from mouse tumour cells was treated with various chemicals. The effects on the immunogenicity of the membrane sample were tested in syngeneic mice for tumour protection, using a challenge dose of 10(5) viable tumour cells. Best protection was obtained after immunization of mice with ...

journal_title：British journal of cancer

authors： Staab HJ,Anderer FA

更新日期：1978-10-01 00:00:00

abstract：:The normal-lymphocyte-transfer test has been advocated as a method of assessing the immuno-competence of lymphocytes from patients with breast and large-bowel cancer. Evidence is presented in this paper that the methodology is subject to many uncontrollable errors, that the reaction is the result of multiple factors, ...

journal_title：British journal of cancer

authors： Gaffney P

更新日期：1978-09-01 00:00:00

abstract：:Nineteen benign human breast tumours, from 19 premenopausal patients, were processed into slices and each tumour was individually cultured for 2 days in Medium 199. The effects of bovine insulin (5.0 microgram/ml) human placental lactogen (10.0 microgram/ml) and human growth hormone (10.0 microgram/ml) on 3H-thymidine...

journal_title：British journal of cancer

authors： Welsch CW,Dombroske SE,McManus MJ

更新日期：1978-08-01 00:00:00

abstract：:Two-tumour-cell-aggregation factors derived from rat ascites hepatoma cells had different antigenicity; one, with a strong potency, was not absorbed by immunoadsorbent chromatography with anti-rat serum antibody and the other, with a weak potency, was. The unabsorbed factor possessed mitogenic activity on lymphocytes ...

journal_title：British journal of cancer

authors： Kuratsu J,Yoshinaga M,Hayashi H

更新日期：1978-08-01 00:00:00

abstract：:The toxicity of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro has been determined as a function of O2 tension. Misonidazole under hypoxic conditions (less than 10 Parts/10(6) O2) shows the greatest toxicity. Split-dose experiments indicate that lethal damage can be "repa...

journal_title：British journal of cancer

authors： Stratford IJ

更新日期：1978-07-01 00:00:00

abstract：:Two techniques for growing colonies of human tumour cells in soft agar have been applied to cell suspensions derived from fresh tumour tissue from 48 patients. Colonies were obtained in 31 cases, with plating efficiencies between 0.01 and 15%. In 11 cases the plating efficiencies were 1% or above. There was evidence t...

journal_title：British journal of cancer

authors： Courtenay VD,Selby PJ,Smith IE,Mills J,Peckham MJ

更新日期：1978-07-01 00:00:00

abstract：:Renal tumours were induced in dietary-primed rats by injection of dimethylnitrosamine. Control and tumour tissue was excised at varying periods and maintained in short-term organ culture in the presence of 3H- or 14C-fucose. The plasma membranes were then isolated, and the isotopic profiles of normal kidney and renal ...

journal_title：British journal of cancer

authors： Whyte A,Loke YW

更新日期：1978-05-01 00:00:00

abstract：:The response of 6 human colorectal tumour xenografts to 7 cytotoxic agents have been established. Tumour responses have been quantified by growth inhibition, and the time taken for 3H-thymidine fractional incorporation (TFI) to recover to the control value after treatment. The chemosensitivity of each tumour line to a...

journal_title：British journal of cancer

authors： Houghton PJ,Houghton JA

更新日期：1978-05-01 00:00:00

abstract：:In mice given a single dose of diethylnitrosamine, a hepatonecrotic dose of carbon tetrachloride, 5 weeks after dosing with DEN and repeated 6 times at 4-weekly intervals, augmented the tumour yield in the livers. A single hepatonecrotic dose of CCl4 24 h before a single dose of DEN also increased the number of tumour...

journal_title：British journal of cancer

authors： Poound AW,McGuire LJ

更新日期：1978-04-01 00:00:00

abstract：:Male inbred Fischer rats were fed phenobarbitone-Na at a level of 500 parts/10(6) in the diet for 1 week, followed by 1000 parts 10(6) for 103 weeks at which time the survivors were killed. Thirty-three treated rats survived to 80 weeks. Before 80 weeks, no animals showed hyperplastic lesions. Of the 33 rats surviving...

journal_title：British journal of cancer

authors： Butler WH

更新日期：1978-03-01 00:00:00

abstract：:RNA tumour virus genes are contained in the chromosomal DNA of most vertebrates, and may be transmitted vertically from parent to progeny along with other cellular genes, as well as horizontally as infectious particles. Activation of these viral genes may be part of the means by which RNA tumour viruses produce cancer...

journal_title：British journal of cancer

authors： Todaro GJ

更新日期：1978-02-01 00:00:00

abstract：:The malignant epithelial cells of nasopharyngeal carcinoma (NPC) and cells of lines derived form the lymphoid cells which infiltrate this tumour have been investigated cytogenetically. Chromosome spreads of lymphoblastoid cells of lines established from 7 different NPC biopsy specimens were examined after banding stai...

journal_title：British journal of cancer

authors： Finerty S,Jarvis JE,Epstein MA,Trumper PA,Ball G,Giovanella BC

更新日期：1978-02-01 00:00:00

abstract：:Bleomycin is a chemotherapuetic drug used primarily in the treatment of squamous-cell carcinoma, while misonidazole is an effective radiosensitizer and potent cytotoxic agent selectively affecting hypoxic cells. V79 Chinese hamster cells were used to investigate the cytotoxicity of bleomycin (BLM) under aerated and hy...

journal_title：British journal of cancer

authors： Roizin-Towle L,Hall EJ

更新日期：1978-02-01 00:00:00

abstract：:The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly...

journal_title：British journal of cancer

authors： Bellamy D,Hinsull SM

更新日期：1978-01-01 00:00:00

abstract：:Seventy-one patients suffering from acute myeloid leukaemia (AML) who were already in complete remission and had already received one further course of cytotoxic drugs as consolidation therapy were randomised to receive maintenance chemotherapy alone or the same maintenance chemotherapy plus immunotherapy with BCG and...

journal_title：British journal of cancer

authors：

更新日期：1978-01-01 00:00:00

abstract：:Alveolar macrophage (AM) phagocytic activity and glucose metabolism were evaluated during lung tumour growth in adult rats challenged i.v. with 10(5) viable Walker 256 tumour cells. Phagocytosis was estimated by the in vitro uptake of (14)C-labelled Pseudomonas aeruginosa and glucose oxidation was evaluated by (14)CO(...

journal_title：British journal of cancer

authors： Gudewicz PW,Saba TM

更新日期：1977-12-01 00:00:00

abstract：:A method for testing organic chemicals for their carcinogenic potential is described. Baby hamster kidney cells (BHK-21/C1 13) were exposed to different doses of test compound in liquid tissue culture medium containing rat liver post-mitochondrial supernatant and cofactors (S-9 mix) to aid metabolism, but without seru...

journal_title：British journal of cancer

authors： Styles JA

更新日期：1977-11-01 00:00:00

abstract：:A comparative study has been made of fibroblasts obtained from patients with differing susceptibilities to malignant disease, both with respect to their chromosome complements and their transformation with SV40 virus. Fibroblasts from 2 Bloom's syndrome patients were found not to have raised SV40 transformation rates ...

journal_title：British journal of cancer

authors： Webb T,Harding M

更新日期：1977-11-01 00:00:00

abstract：:A study is presented of all cases of primary sarcoma of bone registered during the period 1946 to 1974 for a specified population resident in south-western England. Ninety-six per cent of the 365 cases were histologically and radiologically verified and are separated into 8 categories of sarcoma. The number of tumours...

journal_title：British journal of cancer

authors： Price CH,Jeffree GM

更新日期：1977-10-01 00:00:00

abstract：:Twenty-four patients with advanced cancer not reacting to conventional therapy were treated with 97 courses of i.v. MER (methanol extraction residue of BCG). MER was administered by i.v. infusion over a 4-h period, twice a week, in dosages varying from 0.05 mg to 1.25 mg. The skin reactivity to 5 recall antigens was e...

journal_title：British journal of cancer

authors： Robinson E,Bartal A,Honigman J,Cohen Y

更新日期：1977-09-01 00:00:00

abstract：:The function of the reticulo-endothelial system in mice bearing Lewis lung carcinomas has been measured by(1) the rate of clearance of carbon particles from the circulation in vivo and calculation of the phagocytic index K; (2) chemotactic locomotion of macrophages in vitro in the presence or absence of serum or tumou...

journal_title：British journal of cancer

authors： Otu AA,Russell RJ,Wilkinson PC,White RG

更新日期：1977-09-01 00:00:00

abstract：:We report observations on the spread by metastasis and infiltration of a transplantable tumour in rats treated by 60Co gamma-irradiation of the primary, irradiation plus parenteral cyclophosphamide, or parenteral cyclophosphamide alone. The proportion of animals with overt disseminated disease and the extent of spread...

journal_title：British journal of cancer

authors： Moore JV,Dixon B

更新日期：1977-08-01 00:00:00

abstract：:Lines of fibroblasts have been established from normal individuals and from patients diagnosed as suffering from one of the mucopolysaccharidoses or mucopolysaccharide-storage diseases. Transformation of these lines with SV40 virus has been found to reduce their capacity to secrete sulphated mucopolysaccharides into t...

journal_title：British journal of cancer

authors： Webb T

更新日期：1977-07-01 00:00:00